The NIH HEAL (Helping to End Addiction Long-term) Initiative is an interdisciplinary program aimed at advancing addiction and pain research in the United States. The HEAL initiative will bolster research across NIH to improve treatments for opioid misuse and addiction and enhance pain management. The initial plans for the HEAL Initiative include support of research to understand how chronic pain develops as well as develop a data sharing collaborative, new biomarkers for pain, and a clinical trials network for testing new pain therapies.

To learn more about the NIH HEAL Initiative, please visit the NIH HEAL Website.
The following pain-related announcements are listed for your convenience. The complete list of open HEAL initiative funding opportunities can be found at the NIH HEAL Funding Announcements and Opportunities website.

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Title FOA Number News Date Expiration Date Category
Applying a Biopsychosocial Perspective to Self-Management of Chronic Pain (R01 Clinical Trial Optional) PA-18-945 Oct 01, 2018 Jan 08, 2022 Pain Related
Applying a Biopsychosocial Perspective to Self-Management of Chronic Pain (R21 Clinical Trial Optional) PA-18-946 Oct 01, 2018 Jan 08, 2022 Pain Related
Biobehavioral Basis of Chronic Pain (R01 Clinical Trial Optional) PA-18-944 Oct 01, 2018 Jan 08, 2022 Pain Related
Biobehavioral Basis of Chronic Pain (R21 Clinical Trial Optional) PA-18-943 Oct 01, 2018 Jan 08, 2022 Pain Related
Drug Discovery For Nervous System Disorders (R01 Clinical Trials Not Allowed) PAR-19-147 Jan 08, 2019 Jan 08, 2022
Drug Discovery For Nervous System Disorders (R21 Clinical Trial Not Allowed) PAR-19-146 Jan 08, 2019 Jan 08, 2022
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed) RFA-NS-20-009 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required) RFA-NS-20-008 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Not Allowed) RFA-NS-20-011 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Required) RFA-NS-20-010 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) RFA-NS-21-010 Sep 16, 2020 Sep 08, 2022 NIH HEAL Initiative
Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R01 Clinical Trial Optional) PA-19-200 Feb 28, 2019 May 08, 2022 Pain Related
Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R21 Clinical Trial Optional) PA-19-201 Feb 28, 2019 May 08, 2022 Pain Related
NIA Program Project Applications (P01 Clinical Trial Optional) PAR-19-314 Jul 12, 2019 May 26, 2022
Research on Chronic Overlapping Pain Conditions (R01 Clinical Trial Optional) PA-18-937 Sep 26, 2018 Jan 08, 2022 Pain Related
Research on Chronic Overlapping Pain Conditions (R21 Clinical Trial Not Allowed) PA-18-939 Sep 26, 2018 Jan 08, 2022 Pain Related
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Form Approved OMB# 0925-0648 Exp. Date 06/2024