The NIH HEAL (Helping to End Addiction Long-term) Initiative is an interdisciplinary program aimed at advancing addiction and pain research in the United States. The HEAL initiative will bolster research across NIH to improve treatments for opioid misuse and addiction and enhance pain management. The initial plans for the HEAL Initiative include support of research to understand how chronic pain develops as well as develop a data sharing collaborative, new biomarkers for pain, and a clinical trials network for testing new pain therapies.

To learn more about the NIH HEAL Initiative, please visit the NIH HEAL Website.
The following pain-related announcements are listed for your convenience. The complete list of open HEAL initiative funding opportunities can be found at the NIH HEAL Funding Announcements and Opportunities website.

Title NOFO Number News Date Expiration Date Category
HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed) PAR-23-069 Jan 03, 2023 Sep 06, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (Independent Basic Experimental Studies with Humans Required) RFA-NS-22-023 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (K99/R00 Independent Clinical Trial Not Allowed) RFA-NS-22-022 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Basic Experimental Studies with Humans Required) RFA-NS-22-024 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) RFA-NS-22-025 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) PAR-24-197 Apr 17, 2024 Jul 17, 2026 NIH HEAL Initiative, NIH HEAL Initiative
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed) RFA-NS-23-007 Sep 15, 2022 Apr 05, 2025 NIH HEAL Initiative
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed) RFA-NS-23-006 Sep 15, 2022 Apr 05, 2025 NIH HEAL Initiative
HEAL Initiative: JCOIN Phase II Clinical Research Hubs (UM1 Clinical Trial Required) RFA-DA-25-025 Jun 06, 2024 Jan 23, 2025 NIH HEAL Initiative, NIH HEAL Initiative
HEAL Initiative: JCOIN Phase II Community Engaged Research Resource Center (U24 Clinical Trial Optional) RFA-DA-25-026 Jun 06, 2024 Jan 23, 2025 NIH HEAL Initiative, NIH HEAL Initiative
HEAL Initiative: JCOIN Phase II Economic Research Resource Center (U24 Clinical Trial Optional) RFA-DA-25-061 Jun 06, 2024 Jan 23, 2025 NIH HEAL Initiative, NIH HEAL Initiative
HEAL Initiative: JCOIN Phase II Innovation Hubs (R01 Clinical Trial Optional) RFA-DA-25-062 Jun 06, 2024 Jan 23, 2025 NIH HEAL Initiative, NIH HEAL Initiative
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) RFA-NS-25-012 Mar 26, 2024 Jan 16, 2027 NIH HEAL Initiative, NIH HEAL Initiative
HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) RFA-EB-22-002 Aug 23, 2022 Jun 18, 2025 NIH HEAL Initiative
NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Basic Experimental Studies with Humans (BESH) Required) PAR-24-218 Jun 28, 2024 Jul 13, 2027 NIH HEAL Initiative, NIH HEAL Initiative
NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Not Allowed) PAR-24-219 Jun 28, 2024 Jul 13, 2027 NIH HEAL Initiative, NIH HEAL Initiative
NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required) PAR-24-217 Jun 27, 2024 Jul 13, 2027 NIH HEAL Initiative, NIH HEAL Initiative
NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Patient-Oriented Research Career Development award (K23 - Clinical Trial Required) PAR-24-220 Jun 28, 2024 Jul 13, 2027 NIH HEAL Initiative, NIH HEAL Initiative
NIH HEAL Initiative: Coordinated Approaches to Pain Care in Health Care Systems (UG3/UH3 - Clinical Trial Optional) RFA-NS-24-041 May 23, 2024 Nov 08, 2024 NIH HEAL Initiative, NIH HEAL Initiative
Safety and Early Efficacy Studies of Psychedelic-Assisted Therapy for Chronic Pain in Older Adults (UG3/UH3 Clinical Trial Required) RFA-AG-25-004 Apr 24, 2024 Oct 11, 2024 Pain Related, Pain Related
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