The NIH HEAL (Helping to End Addiction Long-term) Initiative is an interdisciplinary program aimed at advancing addiction and pain research in the United States. The HEAL initiative will bolster research across NIH to improve treatments for opioid misuse and addiction and enhance pain management. The initial plans for the HEAL Initiative include support of research to understand how chronic pain develops as well as develop a data sharing collaborative, new biomarkers for pain, and a clinical trials network for testing new pain therapies.

To learn more about the NIH HEAL Initiative, please visit the NIH HEAL Website.
The following pain-related announcements are listed for your convenience. The complete list of open HEAL initiative funding opportunities can be found at the NIH HEAL Funding Announcements and Opportunities website.

Title FOA Number News Date Expiration Date Category
Advancing Research on Mechanisms and Management of Pain for Diseases and Conditions within NIDDK Mission Areas (R01 Clinical Trial Optional) RFA-DK-23-006 Feb 10, 2023 May 05, 2023 Pain Related
HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed) PAR-23-069 Jan 03, 2023 Sep 06, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (Independent Basic Experimental Studies with Humans Required) RFA-NS-22-023 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research (K99/R00 Independent Clinical Trial Not Allowed) RFA-NS-22-022 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Basic Experimental Studies with Humans Required) RFA-NS-22-024 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in PAIN and SUD Research to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) RFA-NS-22-025 Dec 15, 2022 Mar 12, 2025 NIH HEAL Initiative
HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain(RM1 Clinical Trial Optional) RFA-NS-22-069 Nov 04, 2022 Mar 12, 2024 NIH HEAL Initiative
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed) RFA-NS-23-007 Sep 15, 2022 Apr 05, 2025 NIH HEAL Initiative
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed) RFA-NS-23-006 Sep 15, 2022 Apr 05, 2025 NIH HEAL Initiative
HEAL Initiative: Discovery of Biomarkers and Biomarker Signatures to Facilitate Clinical Trials for Pain Therapeutics (UG3/UH3 Clinical Trial Optional) RFA-NS-24-018 Feb 15, 2023 Oct 24, 2023 NIH HEAL Initiative
HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional) RFA-DA-23-053 Aug 03, 2022 Mar 21, 2024 NIH HEAL Initiative
HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed) RFA-EB-22-002 Aug 23, 2022 Jun 18, 2025 NIH HEAL Initiative
Research Network to Promote Multidisciplinary Mechanistic and Translational Studies of Sickle Cell Disease Pain (U24, Clinical Trial Optional) RFA-AT-24-001 Feb 27, 2023 Oct 02, 2023 Pain Related
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