The NIH HEAL (Helping to End Addiction Long-term) Initiative is an interdisciplinary program aimed at advancing addiction and pain research in the United States. The HEAL initiative will bolster research across NIH to improve treatments for opioid misuse and addiction and enhance pain management. The initial plans for the HEAL Initiative include support of research to understand how chronic pain develops as well as develop a data sharing collaborative, new biomarkers for pain, and a clinical trials network for testing new pain therapies.

To learn more about the NIH HEAL Initiative, please visit the NIH HEAL Website.
The following pain-related announcements are listed for your convenience. The complete list of open HEAL initiative funding opportunities can be found at the NIH HEAL Funding Announcements and Opportunities website.

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Title FOA Number News Date Expiration Date Category
Chronic Condition Self-Management in Children and Adolescents (R01 Clinical Trial Optional) PA-18-151 Nov 08, 2017 May 08, 2020
Research Grants Using the Resources from the Osteoarthritis Initiative (OAI) (R21 Clinical Trial Not Allowed) PA-18-408 Oct 26, 2017 May 08, 2021
Administrative Supplements for Research on Sleep Disturbances and Impact on Chronic Pain (Admin Supp) PA-16-164 Apr 04, 2016 Jun 25, 2016 Pain Related
Administrative Supplements for Validation of Novel Non-Addictive Pain Targets (Clinical Trials Not Allowed) NOT-NS-18-073 Aug 23, 2018 Jan 01, 2023 Pain Related
Advancing the Science of Geriatric Palliative Care (R01 - Clinical Trial Optional) PA-18-502 Dec 15, 2017 Sep 08, 2020
Advancing the Science of Geriatric Palliative Care (R21 - Clinical Trial Optional) PA-18-503 Dec 15, 2017 Sep 08, 2020
Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional) RFA-NS-18-046 Sep 19, 2018 Mar 13, 2020 Pain Related
Analytical Validation of a Candidate Biomarker for Neurological Disease (U01) (Clinical Trial Optional) PAR-18-550 Dec 22, 2017 Sep 08, 2020
Analytical Validation of a Candidate Biomarker for Neurological Disease (U44 Clinical Trial Optional) PAR-18-549 Dec 22, 2017 Sep 08, 2020
Applying a Biopsychosocial Perspective to Self-Management of Chronic Pain (R01 Clinical Trial Optional) PA-18-945 Oct 01, 2018 Jan 08, 2022 Pain Related
Applying a Biopsychosocial Perspective to Self-Management of Chronic Pain (R21 Clinical Trial Optional) PA-18-946 Oct 01, 2018 Jan 08, 2022 Pain Related
Biobehavioral Basis of Chronic Pain (R01 Clinical Trial Optional) PA-18-944 Oct 01, 2018 Jan 08, 2022 Pain Related
Biobehavioral Basis of Chronic Pain (R21 Clinical Trial Optional) PA-18-943 Oct 01, 2018 Jan 08, 2022 Pain Related
BRAIN Initiative: Notice of Support for Research on the Fundamental Neurobiology of Pain Processing NOT-NS-18-008 Sep 12, 2017 Jan 01, 2023 Pain Related
Center of Excellence for Research on Complementary and Integrative Health (P01 Clinical Trial Optional) PAR-18-113 Oct 27, 2017 Mar 16, 2020
Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R01) RFA-DA-09-017 Oct 24, 2008 Jan 29, 2009 Pain Related
Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R03) RFA-DA-09-019 Oct 24, 2008 Jan 29, 2009 Pain Related
Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R21) RFA-DA-09-018 Oct 24, 2008 Jan 29, 2009 Pain Related
Chronic Condition Self-Management in Children and Adolescents (R21 Clinical Trial Optional) PA-18-168 Nov 08, 2017 May 08, 2020
Clinical Validation of a Candidate Biomarker for Neurological Disease (U01 Clinical Trial Optional) PAR-18-664 Feb 14, 2018 Sep 08, 2020
Clinical Validation of a Candidate Biomarker for Neurological Disease (U44 Clinical Trial Optional) PAR-18-548 Dec 22, 2017 Sep 08, 2020
Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01 - Clinical Trial Optional) PA-18-917 Sep 10, 2018 Sep 08, 2021 Pain Related
Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01) PA-15-188 Apr 28, 2015 Dec 06, 2017 Pain Related
Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01, Clinical Trial Optional) PA-18-465 Dec 06, 2017 Sep 08, 2018 Pain Related
Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) RFA-NS-18-043 Sep 19, 2018 Nov 13, 2019 Pain Related
Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R21 Clinical Trial Not Allowed) RFA-NS-18-042 Sep 19, 2018 Nov 13, 2019 Pain Related
Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional) RFA-NS-18-041 Aug 02, 2018 Mar 13, 2020 Pain Related
Drug Discovery For Nervous System Disorders (R01 Clinical Trials Not Allowed) PAR-19-147 Jan 08, 2019 Jan 08, 2022
Drug Discovery For Nervous System Disorders (R21 Clinical Trial Not Allowed) PAR-19-146 Jan 08, 2019 Jan 08, 2022
Exploratory Studies in the Neurobiology of Pain in Sickle Cell Disease (R01) RFA-HL-09-008 Nov 13, 2008 Feb 04, 2009 Pain Related
Exploring Epigenomic or Non-Coding RNA Regulation in the Development, Maintenance, or Treatment of Chronic Pain (R61/R33 Clinical Trial Optional) PAR-18-742 Apr 03, 2018 Feb 12, 2021 Pain Related
HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R41/R42 - Clinical Trial Optional) RFA-DA-19-020 Dec 10, 2018 Sep 09, 2021 NIH HEAL Initiative
HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R43/R44 - Clinical Trial Optional) RFA-DA-19-019 Dec 10, 2018 Sep 09, 2021 NIH HEAL Initiative
HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center (U24 Clinical Trial Not Allowed) RFA-AR-19-027 Dec 10, 2018 Mar 21, 2019 NIH HEAL Initiative
HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions. NOT-AR-20-012 Jan 09, 2020 Mar 14, 2020 NIH HEAL Initiative
HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions. NOT-AR-20-016 Jan 15, 2020 Mar 14, 2020 NIH HEAL Initiative
HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Technology Research Sites (UH2/UH3 Clinical Trial Optional) RFA-AR-19-028 Dec 10, 2018 Mar 21, 2019 NIH HEAL Initiative
HEAL Initiative: Back Pain Consortium (BACPAC) Research Program: Mechanistic Research Centers (U19 Clinical Trial Optional) RFA-AR-19-026 Dec 10, 2018 Mar 21, 2019 NIH HEAL Initiative
HEAL Initiative: Back Pain Consortium (BACPAC) Research Program: Phase 2 Clinical Trials (UG3/UH3 Clinical Trial Required) RFA-AR-19-029 Dec 10, 2018 Feb 27, 2019 NIH HEAL Initiative
HEAL Initiative: Biofabricated 3D Tissue Models of Nociception, Opioid Use Disorder and Overdose for Drug Screening (UH2/UH3 Clinical Trial Not Allowed) RFA-TR-19-005 Dec 10, 2018 Mar 01, 2019 NIH HEAL Initiative
HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional) RFA-NS-19-018 Dec 10, 2018 Apr 16, 2020 NIH HEAL Initiative
HEAL Initiative: Data Coordinating Center for the Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial (U24 Clinical Trial Required) RFA-HD-21-032 Jan 11, 2021 Mar 31, 2021 NIH HEAL Initiative
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed) RFA-NS-20-009 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required) RFA-NS-20-008 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Not Allowed) RFA-NS-20-011 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Required) RFA-NS-20-010 Oct 04, 2019 Sep 09, 2022 NIH HEAL Initiative
HEAL Initiative: Early Phase Pain Investigation Clinical Network - Clinical Coordinating Center (U24 Clinical Trial Not Allowed RFA-NS-19-023 Dec 10, 2018 Feb 07, 2019 NIH HEAL Initiative
HEAL Initiative: Early Phase Pain Investigation Clinical Network - Data Coordinating Center (U24 Clinical Trials Not Allowed) RFA-NS-19-024 Dec 10, 2018 Feb 07, 2019 NIH HEAL Initiative
HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed) RFA-NS-19-025 Dec 10, 2018 Feb 07, 2019 NIH HEAL Initiative
HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed) RFA-NS-19-036 Apr 18, 2019 Jun 04, 2019 NIH HEAL Initiative
HEAL Initiative: HEALthy Brain and Child Development Consortium Administrative Core (U24 - Clinical Trial Not Allowed) RFA-DA-21-022 Jan 11, 2021 Apr 01, 2021 NIH HEAL Initiative
HEAL Initiative: HEALthy Brain and Child Development Data Coordinating Center (U24) RFA-DA-21-023 Jan 11, 2021 Apr 01, 2021 NIH HEAL Initiative
HEAL Initiative: HEALthy Brain and Child Development Study (Collaborative U01- Clinical Trial Not Allowed) RFA-DA-21-020 Jan 11, 2021 Apr 01, 2021 NIH HEAL Initiative
HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) ( R34- Clinical Trial Not Allowed) RFA-DA-19-036 Dec 21, 2018 Mar 26, 2019 NIH HEAL Initiative
HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) (Collaborative R34- Clinical Trial Not Allowed) RFA-DA-19-029 Dec 21, 2018 Mar 26, 2019 NIH HEAL Initiative
HEAL Initiative: HEALthy Brain and Child Development Study (U01 - Clinical Trial Not Allowed) RFA-DA-21-021 Jan 11, 2021 Apr 01, 2021 NIH HEAL Initiative
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional) RFA-DA-21-029 Jan 11, 2021 Apr 01, 2021 NIH HEAL Initiative
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required) RFA-DA-21-030 Jan 11, 2021 Apr 01, 2021 NIH HEAL Initiative
HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial - Clinical Sites (UG1 Clinical Trial Required) RFA-HD-21-031 Jan 11, 2021 Mar 31, 2021 NIH HEAL Initiative
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) RFA-NS-21-010 Sep 16, 2020 Sep 08, 2022 NIH HEAL Initiative
HEAL Initiative: Notice of Interest in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at Enhanced Pain Management and Improved Treatments for Opioid Misuse and Addiction NOT-NS-19-014 Dec 10, 2018 Jan 01, 2023 NIH HEAL Initiative
HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Reduce Stigma in Pain Management and Opioid Use Disorder (OUD) and Treatment NOT-OD-20-101 Apr 23, 2020 May 30, 2020 NIH HEAL Initiative
HEAL Initiative: Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain - (U44 Clinical Trial Not Allowed) RFA-NS-19-020 Dec 10, 2018 Jun 05, 2019 NIH HEAL Initiative
HEAL Initiative: Optimizing Multi-Component Service Delivery Interventions for People with Opioid Use Disorder, Co-Occurring Conditions, and/or Suicide Risk (R01 Clinical Trials Optional) RFA-MH-21-145 Jan 11, 2021 Mar 19, 2021 NIH HEAL Initiative
HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) RFA-NS-19-021 Dec 10, 2018 Feb 12, 2019 NIH HEAL Initiative
HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) RFA-NS-20-028 Jan 21, 2020 Jun 25, 2020 NIH HEAL Initiative
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) RFA-AT-19-004 Dec 10, 2018 Feb 09, 2019 NIH HEAL Initiative
HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) RFA-AT-20-004 Jan 23, 2020 Jun 30, 2020 NIH HEAL Initiative
HEAL Initiative: Stimulating Peripheral Activity to Relieve Conditions (SPARC): Anatomical and Functional Mapping of Pain-Related Visceral Organ Neural Circuitry (U01 Clinical Trial Optional) RFA-RM-19-001 Dec 10, 2018 Feb 09, 2019 NIH HEAL Initiative
HEAL Initiative: Tissue Chips to Model Nociception, Addiction, and Overdose (UG3/UH3 Clinical Trial Not Allowed) RFA-TR-19-003 Dec 10, 2018 Mar 01, 2019 NIH HEAL Initiative
HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed) RFA-EB-18-003 Dec 10, 2018 Apr 16, 2020 NIH HEAL Initiative
HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional) RFA-NS-19-017 Dec 10, 2018 Apr 16, 2020 NIH HEAL Initiative
HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional) RFA-NS-19-016 Dec 10, 2018 Apr 16, 2020 NIH HEAL Initiative
HEAL/NINDS Early Phase Pain Investigation Clinical Network (EPPIC-Net): Opening to applications for non-addictive pain therapeutics NOT-NS-19-075 Sep 11, 2019 Jan 01, 2023 NIH HEAL Initiative
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Assay Development and Neurotherapeutic Agent Identification (R61/R33 Clinical Trial Not Allowed) PAR-18-762 Apr 19, 2018 May 08, 2021
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems and/or Pharmacodynamic Markers to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed) PAR-18-763 Apr 19, 2018 May 08, 2021
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Neurotherapeutic Agent Characterization and In vivo Efficacy Studies (R61/R33 Clinical Trial Not Allowed) PAR-18-761 Apr 19, 2018 May 08, 2021
Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R01 Clinical Trial Optional) PA-19-200 Feb 28, 2019 May 08, 2022 Pain Related
Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R21 Clinical Trial Optional) PA-19-201 Feb 28, 2019 May 08, 2022 Pain Related
Mechanisms, Models, Measurement, & Management in Pain Research (R01)
PA-13-118 Feb 15, 2013 Apr 14, 2016 Pain Related
Mechanisms, Models, Measurement, & Management in Pain Research (R01) PA-06-544 Aug 31, 2006 Jan 03, 2007 Pain Related
Mechanisms, Models, Measurement, & Management in Pain Research (R03)
PA-13-117 Feb 15, 2013 May 08, 2016 Pain Related
Mechanisms, Models, Measurement, & Management in Pain Research (R03) PA-06-543 Aug 31, 2006 Jan 08, 2010 Pain Related
Mechanisms, Models, Measurement, & Management in Pain Research (R21)
PA-13-119 Feb 15, 2013 Apr 14, 2016 Pain Related
Mechanisms, Models, Measurement, & Management in Pain Research (R21) PA-06-542 Aug 31, 2006 Jan 08, 2010 Pain Related
Mechanisms, Models, Measurement, & Management in Pain Research (R21) PA-10-007 Oct 05, 2009 Jan 08, 2013 Pain Related
Mechanisms, Models, Measurement, and Management in Pain Research (R01 Clinical Trial Optional) PA-18-141 Nov 07, 2017 May 08, 2021 Pain Related
Mechanisms, Models, Measurement, and Management in Pain Research (R01) PA-07-282 Jan 08, 2007 Jan 08, 2010 Pain Related
Mechanisms, Models, Measurement, and Management in Pain Research (R01) PA-10-006 Oct 05, 2009 Jan 08, 2013 Pain Related
Mechanisms, Models, Measurement, and Management in Pain Research (R01) PA-16-188 Apr 14, 2016 Jan 25, 2018 Pain Related
Mechanisms, Models, Measurement, and Management in Pain Research (R03) PA-10-008 Oct 05, 2009 Jan 08, 2013 Pain Related
Mechanisms, Models, Measurement, and Management in Pain Research (R21 Clinical Trial Optional) PA-18-159 Nov 07, 2017 Jan 08, 2020 Pain Related
Mechanisms, Models, Measurement, and Management in Pain Research (R21) PA-16-187 Apr 14, 2016 Jan 25, 2018 Pain Related
Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network (U01) RFA-DK-07-003 Sep 19, 2007 Jan 10, 2008 Pain Related
Neurobiology Of Persistent Pain Mediated By The Trigeminal Nerve (R21) PAS-06-199 Mar 03, 2006 Jul 01, 2006 Pain Related
NIA Program Project Applications (P01 Clinical Trial Optional) PAR-19-314 Jul 12, 2019 May 26, 2022
NIH Blueprint for Neuroscience Research Competitive Revisions for Studies Focused on Neuropathic Pain or Neural Plasticity to Promote Collaborative Pain Research (R01) PAR-09-264 Sep 22, 2009 Nov 24, 2009 Pain Related
NIH Blueprint for Neuroscience Research Competitive Revisions for Studies Focused on Neuropathic Pain or Neural Plasticity to Promote Collaborative Pain Research (R01) PAR-10-204 May 21, 2010 Sep 29, 2012 Pain Related
NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01) RFA-DE-11-002 May 07, 2010 Sep 30, 2010 Pain Related
NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01) RFA-DE-12-008 Jun 30, 2011 Oct 05, 2011 Pain Related
NIH-DoD-VA Pain Management Collaboratory - Pragmatic Clinical Trials Demonstration Projects (UG3/UH3) RFA-AT-17-001 Dec 12, 2016 Mar 04, 2017 Pain Related
NINDS Notice to Clarify the Types of Clinical Trial Applications NINDS Will Support Under PA-18-141 "Mechanisms, Models, Measurement, & Management in Pain Research (R01 Clinical Trial Optional)" NOT-NS-18-017 Mar 09, 2018 Jan 01, 2023 Pain Related
NINDS Notice to Clarify the Types of Clinical Trial Applications NINDS Will Support Under PA-18-159 "Mechanisms, Models, Measurement, & Management in Pain Research (R21 - Clinical Trial Optional)" NOT-NS-18-016 Mar 19, 2018 Jan 01, 2023 Pain Related
Notice of Change in Expiration Date and Cancellation of Final Three Receipt Dates for RFA-NS-19-016 "HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional)." NOT-NS-20-047 Apr 14, 2020 Jan 01, 2023 NIH HEAL Initiative
Notice of Change in Expiration Date and Cancellation of Final Three Receipt Dates for RFA-NS-19-017 "HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)." NOT-NS-20-048 Apr 14, 2020 Jan 01, 2023 NIH HEAL Initiative
Notice of Change in Expiration Date and Cancellation of Final Three Receipt Dates for RFA-NS-19-018 "HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)." NOT-NS-20-049 Apr 14, 2020 Jan 01, 2023 NIH HEAL Initiative
Notice of Change in Expiration Date of RFA-EB-18-003 "HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed)" NOT-EB-20-009 Apr 13, 2020 Jan 01, 2023 NIH HEAL Initiative
Notice of Change of Requirements and Interest in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at Enhanced Pain Management and Improved Treatments for Opioid Misuse and Addiction NOT-NS-18-076 Jul 23, 2018 Jan 01, 2023 Pain Related
Notice of Change to Key Dates and Change to Matching Requirement Instructions for RFA-NS-19-010 "Optimization of Non-Addictive Therapies (Small Molecules and Biologics) to Treat Pain (UG3/UH3 Clinical Trial Not Allowed)" NOT-NS-19-026 Dec 03, 2018 Jan 01, 2023 Pain Related
Notice of Change to Key Dates for RFA-EB-18-003 "HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed)" NOT-NS-19-056 Apr 10, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Change to Key Dates for RFA-NS-19-016 "HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional)" NOT-NS-19-053 Apr 10, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Change to Key Dates for RFA-NS-19-017 "HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)" NOT-NS-19-054 Apr 10, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Change to Key Dates for RFA-NS-19-018 "HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)" NOT-NS-19-055 Apr 10, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Change to Key Dates for RFA-NS-19-021 "HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)" NOT-NS-19-028 Jan 02, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Clarification to RFA-NS-18-042, "Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R21 Clinical Trial Not Allowed)" NOT-AT-19-026 May 07, 2019 Jan 01, 2023 Pain Related
Notice of Clarification to RFA-NS-18-043, "Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)" NOT-AT-19-024 May 07, 2019 Jan 01, 2023 Pain Related
Notice of Clarification: Research Strategy page limit for RFA-NS-18-046 Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional) NOT-NS-19-004 Oct 15, 2018 Jan 01, 2023 Pain Related
Notice of Correction to Application Types Allowed for RFA-NS-19-017 "HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)" NOT-NS-19-052 Apr 10, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Correction to Cooperative Agreement Terms and Conditions of Award for RFA-NS-19-020 "HEAL Initiative: Optimization of Non-addictive Therapies (Small Molecules and Biologics) to Treat Pain (U44 - Clinical Trial Not Allowed)". NOT-NS-19-033 Feb 05, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Information: Clinical Trials that Explore Non-Addictive Therapeutics for Pain Conditions under the Early Phase Pain Investigation Clinical Network (EPPIC-Net) NOT-NS-19-043 Mar 13, 2019 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for Analytical and Clinical Validation of Biomarkers, Biomarker Signatures, and Endpoints for Pain Indications (R61/R33) NOT-NS-18-074 Jul 23, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for Clinical Centers for the Clinical Trials Network on Pain Research (CTNPR) (U24 Clinical Trial Not Allowed) NOT-NS-18-069 Jun 14, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for Clinical Trials Network on Pain Research Clinical Coordinating Center (U24 Clinical Trials not Allowed) NOT-NS-18-058 Jun 14, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for Clinical Trials Network on Pain Research - Data Coordinating Center (U24 Clinical Trial Not Allowed) NOT-NS-18-057 Jun 14, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for Development of Translational Devices to Treat Pain (U18 Clinical Trial Not Allowed) NOT-EB-18-030 Oct 22, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed) NOT-NS-18-080 Aug 23, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) NOT-NS-20-106 Sep 08, 2020 Jan 01, 2023 NIH HEAL Initiative
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) NOT-NS-20-020 Dec 26, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Pain Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) NOT-NS-19-022 Nov 27, 2018 Jan 01, 2023 NIH HEAL Initiative
Notice of Intent to Publish a Funding Opportunity Announcement for Translational Devices to Treat Pain (U44 Clinical Trial Optional) NOT-NS-19-010 Oct 22, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish a Funding Opportunity Announcement for Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional) NOT-NS-19-009 Oct 23, 2018 Jan 01, 2023 Pain Related
Notice of Intent to Publish the Reissuance of PA-10-007 Mechanisms, Models, Measurement, & Management in Pain Research (R21) NOT-NR-13-009 Jan 25, 2013 Jan 01, 2023 Pain Related
Notice of Intent to Publish the Reissuance of "RFA-NS-19-025" "HEAL Initiative: Early Phase Pain Investigation Clinical Network - Specialized Clinical Centers (U24 Clinical Trial Not Allowed)" NOT-NS-19-051 Apr 11, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Intent to Publish the Reissuance of PA-10-006 Mechanisms, Models, Measurement, & Management in Pain Research (R01) NOT-NR-13-007 Jan 25, 2013 Jan 01, 2023 Pain Related
Notice of Intent to Publish the Reissuance of PA-10-008 Mechanisms, Models, Measurement, & Management in Pain Research (R03) NOT-NR-13-008 Jan 25, 2013 Jan 01, 2023 Pain Related
Notice of National Institute of Neurological Disorders and Stroke (NINDS) and National Institute on Drug Abuse (NIDA) Interest in Blueprint Neurotherapeutic Network Applications Directed at Small Molecule Non-Addictive Pain Therapies NOT-NS-18-027 Dec 13, 2017 Jan 01, 2023 Pain Related
Notice of National Institute of Neurological Disorders and Stroke (NINDS) IGNITE and CREATE Bio Program Applications Directed at Non-Addictive Pain Therapies NOT-NS-18-048 Mar 05, 2018 Jan 01, 2023 Pain Related
Notice of National Institute of Neurological Disorders and Stroke (NINDS) Interest in Biomarkers Directed at Pain or Pain Therapies NOT-NS-18-043 Feb 15, 2018 Jan 01, 2023 Pain Related
Notice of National Institute of Neurological Disorders and Stroke (NINDS) Participation in PA-16-164 "Administrative Supplements for Research on Sleep Disturbances and Impact on Chronic Pain (Admin Supp)" NOT-NS-16-020 Apr 26, 2016 Jan 01, 2023 Pain Related
Notice of NIH Pre-Application Webinar for RFA-NS-20-028 "HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)". NOT-NS-20-027 Feb 06, 2020 Jan 01, 2023 NIH HEAL Initiative
Notice of NINDS BRG, BRP, Translational Neural Devices, BRAIN Initiative: Next Generation Invasive Devices Recording, Modulation in the Human Central Nervous System, and Smart & Connected Health Program Applications Directed at the Treatment of Pain NOT-NS-18-052 Mar 27, 2018 Jan 01, 2023 Pain Related
Notice of NINDS Participation in PA-18-917 "Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01 - Clinical Trial Optional)" NOT-NS-20-036 Jan 03, 2020 Jan 01, 2023 Pain Related
Notice of Removal of Cost Matching Requirements for RFA-NS-21-010 "HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)" NOT-NS-21-016 Nov 25, 2020 Jan 01, 2023 NIH HEAL Initiative
Notice of Removal of Matching Requirement Instructions for RFA-NS-19-016 "HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional)". NOT-NS-19-030 Feb 05, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Removal of Matching Requirement Instructions for RFA-NS-19-017 "HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional)". NOT-NS-19-031 Feb 05, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Removal of Matching Requirement Instructions for RFA-NS-19-018 "HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)". NOT-NS-19-032 Feb 05, 2019 Jan 01, 2023 NIH HEAL Initiative
Notice of Removal of Matching Requirements for RFA-NS-18-041 Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional) NOT-NS-19-044 Mar 06, 2019 Jan 01, 2023 Pain Related
Notice of Removal of Matching Requirements for RFA-NS-18-046 Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional) NOT-NS-19-037 Mar 06, 2019 Jan 01, 2023 Pain Related
Notice of Special Interest for HEAL Initiative: Request for Administrative Supplements to Existing Grants for Identification and Validation of New Pain and Opioid Use Disorder Targets within the Understudied Druggable Genome NOT-TR-20-008 Mar 10, 2020 Jun 02, 2020 NIH HEAL Initiative
Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Promote Training in Clinical Research on Pain (Admin Supp Clinical Trial Not Allowed) NOT-NS-20-044 Apr 10, 2020 Jul 31, 2020 NIH HEAL Initiative
Notice to Extend the Expiration Date for PA-18-141 "Mechanisms, Models, Measurement, & Management in Pain Research (R01 Clinical Trial Optional)" NOT-NS-19-061 May 07, 2019 Jan 01, 2023 Pain Related
Notice to Extend the Expiration Date for PA-18-141 "Mechanisms, Models, Measurement, & Management in Pain Research (R01 Clinical Trial Optional)" NOT-NS-20-003 Aug 19, 2019 Jan 01, 2023 Pain Related
Notice to Extend the Expiration Date for PA-18-141 "Mechanisms, Models, Measurement, & Management in Pain Research (R01 Clinical Trial Optional)" NOT-NS-20-021 Dec 18, 2019 Jan 01, 2023 Pain Related
Notice to Extend the Expiration Date for PA-18-159 "Mechanisms, Models, Measurement, & Management in Pain Research (R21 Clinical Trial Optional)" NOT-NS-19-062 May 07, 2019 Jan 01, 2023 Pain Related
Notice to Extend the Expiration Date for PA-18-159 "Mechanisms, Models, Measurement, & Management in Pain Research (R21 Clinical Trial Optional)" NOT-NS-20-004 Aug 19, 2019 Jan 01, 2023 Pain Related
Notice to Extend the Expiration Date for PA-18-159 "Mechanisms, Models, Measurement, & Management in Pain Research (R21 Clinical Trial Optional)" NOT-NS-20-022 Dec 18, 2019 Jan 01, 2023 Pain Related
Notice to Extend the Expiration Date for RFA-NS-19-010 "Optimization of Non-addictive Therapies (Small Molecules and Biologics) to Treat Pain (UG3/UH3 Clinical Trial Not Allowed)" NOT-NS-19-040 Mar 07, 2019 Jan 01, 2023 Pain Related
Notice to Extend the Expiration Date for RFA-NS-19-020 "Optimization of Non-addictive Therapies (Small Molecules and Biologics) to Treat Pain (U44 Clinical Trial Not Allowed)" NOT-NS-19-042 Mar 07, 2019 Jan 01, 2023 Pain Related
Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Not Allowed) RFA-NS-19-010 Nov 05, 2018 Jun 05, 2019 Pain Related
Request for Information: Input on the Development of the Federal Pain Research Strategy. NOT-NS-16-038 Aug 12, 2015 Jan 01, 2023 Pain Related
RESCINDED - Notice of Removal of Matching Requirements for RFA-NS-18-041 Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional) NOT-NS-19-036 Feb 14, 2019 Jan 01, 2023 Pain Related
Research Grants Using the Resources from the Osteoarthritis Initiative (OAI) (R01 Clinical Trial Not Allowed) PA-18-409 Oct 26, 2017 May 08, 2021
Research on Chronic Overlapping Pain Conditions (R01 Clinical Trial Optional) PA-18-937 Sep 26, 2018 Jan 08, 2022 Pain Related
Research on Chronic Overlapping Pain Conditions (R01) PA-14-244 Jun 04, 2014 Sep 08, 2017 Pain Related
Research on Chronic Overlapping Pain Conditions (R21 Clinical Trial Not Allowed) PA-18-939 Sep 26, 2018 Jan 08, 2022 Pain Related
Research on Chronic Overlapping Pain Conditions (R21) PA-14-243 Jun 04, 2014 Sep 08, 2017 Pain Related
Self-Management for Health in Chronic Conditions (R01 Clinical Trial Optional) PA-18-376 Dec 18, 2017 Jan 08, 2021
Self-Management for Health in Chronic Conditions (R21 Clinical Trial Optional) PA 18-384 Dec 18, 2017 Jan 08, 2021
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Form Approved OMB# 0925-0648 Exp. Date 06/2024